tert-Butyllithium
tert-Butyllithium (CAS:594-19-4) is one of the strongest commercially available organolithium bases. Its bulky tert-butyl group enables extremely fast lithium-halogen exchange and complete deprotonation of weakly acidic substrates, making it indispensable in high-demand organic synthesis and pharmaceutical intermediate manufacturing. The Industrial Grade specification is maintained by disciplined manufacturing and full analytical release, with COA, technical and safety documentation accompanying each order. Combined with 25kg/drum, 200kg/drum packaging options and dependable worldwide delivery, this quality system gives formulators and distributors a low-risk, high-continuity source they can qualify once and rely on for years.
When sourcing tert-Butyllithium (CAS:594-19-4), KieRay Chem stands out with stable quality, competitive pricing and responsive service built on long-term production expertise. We maintain strict quality assurance on assay, trace impurities and physical specifications, and every order ships with complete COA, TDS and SDS support. Competitive pricing, long-term stock availability and made-to-order grades give customers supply security for years of collaboration. Partner with KieRay Chem for predictable quality, on-time delivery and a truly dependable supply source for your business growth.
1. **tert-Butyllithium (CAS 594-19-4): A Powerful Organolithium Reagent**
tert-Butyllithium, commonly abbreviated as t-BuLi, is a highly reactive organolithium compound used in advanced synthetic chemistry. Recognized by CAS Number 594-19-4, it combines strong basicity with nucleophilic reactivity, making it useful for controlled deprotonation and the generation of organolithium intermediates. Its distinctive performance supports demanding laboratory and process chemistry applications.
2. **Applications in Organic and Medicinal Chemistry**
tert-Butyllithium is widely selected for challenging organic synthesis procedures that require efficient metalation or the formation of reactive carbon-based species. These intermediates can undergo further reactions to construct complex molecular frameworks. Accordingly, t-BuLi is relevant to medicinal chemistry, pharmaceutical intermediate research, agrochemical development, and specialty molecule synthesis, where reaction precision and route efficiency are important.
3. **Value for Research, Process Development, and Materials Science**
In addition to small-molecule synthesis, tert-Butyllithium can support investigations into organometallic reaction mechanisms, functionalized materials, polymer chemistry, and process optimization. Researchers may use this reagent to explore new transformations, improve synthetic routes, and develop high-value chemical intermediates. Its strong reactivity makes careful experimental design essential for obtaining consistent and reproducible results.
4. **Key Purchasing and Quality Considerations**
When sourcing tert-Butyllithium 594-19-4, buyers should verify concentration, solvent, purity, packaging, batch consistency, certificate of analysis, and available technical documentation. Reliable specifications improve traceability and supplier comparison. Useful search terms include tert-Butyllithium, t-BuLi, organolithium reagent, strong base, metalation reagent, CAS 594-19-4, and pharmaceutical research chemical.
5. **Professional Handling and Regulatory Compliance**
tert-Butyllithium is extremely reactive and can ignite spontaneously in air or react violently with water and incompatible substances. It must be handled only by trained professionals in suitable facilities, using the supplier’s Safety Data Sheet, applicable regulations, and validated institutional procedures. This product is intended for professional research and industrial use only, not for medical, diagnostic, food, or household applications. Confirm current specifications before purchase or use.
Product Name: tert-Butyllithium
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