Lithium dodecyl sulphate
Lithium dodecyl sulphate (CAS 2044-56-6), commonly abbreviated as LDS, is an anionic surfactant and detergent characterized by a 12-carbon alkyl chain attached to a lithium sulfate group. It functions similarly to sodium dodecyl sulfate but possesses distinct solubility and precipitation profiles, particularly remaining soluble at lower temperatures where other salts precipitate out. In biochemical and analytical laboratories, LDS is a crucial reagent for disrupting cell membranes and denaturing proteins for gel electrophoresis applications. Its unique counter-ion properties make it especially valuable for specialized protein separation and characterization protocols under chilled conditions.
– Protein Electrophoresis (PAGE): Utilized as an anionic detergent in place of sodium dodecyl sulfate for resolving proteins via polyacrylamide gel electrophoresis under low-temperature conditions.
– Cell Lysis and Extraction: Incorporated into specialized lysis buffers to effectively disrupt cellular membranes and solubilize membrane-bound proteins for proteomic analysis.
– Chromatographic Separations: Employed as an additive in micellar electrokinetic chromatography to optimize selectivity and separation parameters for complex biomolecules.
Product Name: Lithium dodecyl sulphate
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