-4-benzyl-2-[-1-[3,5-bisphenyl]ethoxy]morpholin-3-one
(2R)-4-Benzyl-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}morpholin-3-one (CAS 287930-75-0) is a complex chiral organic molecule containing morpholinone and bis(trifluoromethyl)phenyl structural motifs. It is primarily recognized as a critical advanced pharmaceutical intermediate used in the stereoselective synthesis of active pharmaceutical ingredients, most notably neurokinin-1 receptor antagonists such as aprepitant. The molecule’s defined stereocenters and robust functional architecture require rigorous synthesis and purification controls to ensure high enantiomeric purity. Its primary commercial significance lies in enabling the precise construction of complex therapeutic molecules targeting central nervous system pathways.
– Pharmaceutical Synthesis Intermediate: Employed as a key chiral building block for synthesizing antiemetic drugs and neurokinin-1 receptor antagonists used in chemotherapy-induced nausea management.
– Asymmetric Synthesis Research: Utilized in advanced organic chemistry laboratories for developing stereoselective reaction pathways and chiral auxiliary methods.
– Drug Discovery Development: Served as a structural scaffold in medicinal chemistry research programs investigating novel treatments for psychiatric and neurological disorders.
Product Name: -4-benzyl-2-[-1-[3,5-bisphenyl]ethoxy]morpholin-3-one
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