O-benzylglycine toluene-p-sulphonate
O-benzylglycine toluene-p-sulphonate (CAS: 1738-76-7) is a protected amino acid derivative consisting of glycine benzyl ester paired with p-toluenesulfonic acid. The benzyl ester protects the carboxyl group during peptide coupling reactions, while the salt form provides a crystalline, easily handled solid that stabilizes the free amine. Upon completion of synthetic transformations, the benzyl group is readily removed by hydrogenolysis or hydrolysis to reveal the free carboxylic acid. This compound is a standard building block in peptide synthesis and pharmaceutical intermediate manufacturing, enabling stepwise elongation of peptide chains with minimal racemization. It also serves as a starting material for N-substituted glycine derivatives and heterocyclic compounds in drug discovery. Supplied as a high-purity crystalline solid, it offers dependable reactivity and storage stability for multi-step synthetic programs.
– Peptide Synthesis: Used as a carboxyl-protected glycine building block in solid-phase and solution-phase peptide assembly for pharmaceutical research.
– API Intermediate: Serves as a starting material for the synthesis of N-substituted amino acids and glycine-derived drug candidates.
– Protecting Group Chemistry: The benzyl ester is readily cleaved by hydrogenolysis, enabling clean deprotection under mild conditions in multi-step routes.
– Heterocycle Construction: Applied in the synthesis of morpholinones, diketopiperazines, and other heterocycles derived from protected amino acids.
Product Name: O-benzylglycine toluene-p-sulphonate
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