Atazanavir Sulfate
Atazanavir Sulfate (CAS: 229975-97-7) is the sulfate salt of atazanavir, an azapeptide protease inhibitor widely used in antiretroviral therapy for the treatment of HIV-1 infection. By selectively binding to the HIV-1 protease enzyme, it prevents the cleavage of viral polyproteins into functional components, thereby blocking viral maturation and the production of infectious virions. The sulfate salt form enhances aqueous solubility and formulation stability for oral administration, typically in capsule or powder form often boosted with ritonavir to improve pharmacokinetic exposure. Atazanavir is valued in treatment regimens for its once-daily dosing, favorable lipid profile compared to earlier protease inhibitors, and established safety record in both treatment-naive and experienced patients. As a prescription pharmaceutical active ingredient, it is manufactured under strict GMP conditions with comprehensive quality control. Proper storage and handling per pharmacopeial requirements ensure maintained potency and patient safety.
– HIV Antiretroviral Therapy: Used as a first-line protease inhibitor in combination regimens for the treatment of HIV-1 infection in adults and pediatric patients.
– Oral Pharmaceutical Formulations: Supplied as the sulfate salt for capsule and oral powder formulations enabling once-daily dosing with ritonavir boosting.
– Hospital and Clinical Pharmacy: Incorporated into standardized antiretroviral protocols for treatment-naive and treatment-experienced patients under medical supervision.
Product Name: Atazanavir Sulfate
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