1,3-Dioxolane-4-methanol, 2–2–, 4-methanesulfonate,-rel-
1,3-Dioxolane-4-methanol, 2–2–, 4-methanesulfonate (CAS: 67914-86-7) is a functionalized dioxolane intermediate bearing a methanesulfonate leaving group on a chlorinated heterocyclic framework. The activated mesylate enables efficient nucleophilic displacement by amines, alkoxides, and other nucleophiles, making this compound a strategic building block in pharmaceutical synthesis, particularly for constructing chiral side chains and heterocyclic cores of cardiovascular and central nervous system drugs. The dioxolane ring provides a protected carbonyl equivalent and conformational rigidity that carries through to derived products. The compound is typically manufactured under strict quality control to ensure defined stereochemistry and low impurity levels essential for API production. Proper storage in sealed containers away from moisture preserves its reactivity for demanding multi-step transformations in regulated manufacturing environments.
– Pharmaceutical Intermediate: Used as an activated building block for introducing dioxolane-containing side chains into drug candidates through nucleophilic substitution.
– Chiral Synthesis: Serves as a stereochemically defined scaffold for constructing optically active pharmaceutical intermediates.
– Nucleophilic Displacement: Applied in amination and etherification reactions where the mesylate group provides clean, high-yielding conversions.
– Process Development: Employed in API route scouting and scale-up for heterocyclic drug manufacturing.
Product Name: 1,3-Dioxolane-4-methanol, 2–2–, 4-methanesulfonate,-rel-
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