Diethylmalonate
Diethylmalonate (CAS: 87-13-8), specifically diethyl ethoxymethylenemalonate (EMME), is a highly functionalized malonate derivative featuring an activated ethoxymethylene group that dramatically enhances its reactivity toward nitrogen nucleophiles. This pale liquid is a cornerstone intermediate in heterocyclic synthesis, readily undergoing cyclocondensation with amidines, guanidines, and o-phenylenediamines to construct pyrimidines, quinazolines, and benzimidazoles of pharmaceutical significance. It is a key building block in the synthesis of vitamin B1, the antimalarial pyrimethamine, and numerous antihypertensive and anti-inflammatory agents. The two ester groups provide additional handles for hydrolysis, decarboxylation, and further functionalization. Supplied as a high-purity reagent, EMME delivers consistent cyclization yields in both laboratory and industrial-scale operations, making it indispensable for heteroaromatic chemistry.
– Heterocycle Synthesis: Used to construct pyrimidines, quinazolines, and pyridopyrimidines through condensation with amidines and o-aminoaryl reagents.
– Vitamin and API Manufacturing: Serves as a key intermediate in vitamin B1 synthesis and antimalarial, antihypertensive, and anticancer drug production.
– Reactive Malonate Chemistry: Applied in Knoevenagel-type condensations and carbon-carbon bond forming reactions for fine chemical synthesis.
– Flavor and Fragrance: Employed in synthesizing heterocyclic aroma compounds for food and perfumery applications.
Product Name: Diethylmalonate
For global customers, we provide complete technical documentation to support product evaluation, regulatory compliance and safe handling during transportation and application.