Diethylethoxy)methyl)phosphonate
Diethylethoxy)methyl)phosphonate (CAS: 116384-53-3) is an acyclic nucleotide phosphonate intermediate featuring a diethyl phosphonate ester and a purine base connected through an ethoxy linker. This compound serves as a key intermediate in the synthesis of tenofovir and related antiretroviral agents used in HIV and hepatitis B treatment. The phosphonate moiety provides metabolic stability mimicking the natural phosphate while resisting enzymatic hydrolysis, and the diethyl ester can be hydrolyzed or selectively functionalized to the active form. The purine base confers antiviral activity through viral reverse transcriptase inhibition. Manufactured under stringent quality controls to ensure high purity and minimal isomeric impurities, this intermediate supports efficient multi-step synthesis of nucleotide reverse transcriptase inhibitors. Proper storage in dry conditions preserves phosphonate integrity for demanding pharmaceutical transformations.
– Tenofovir Synthesis: Used as a key phosphonate intermediate in manufacturing tenofovir disoproxil and alafenamide for HIV and HBV therapy.
– Nucleotide Analog Chemistry: Serves as a building block for acyclic nucleoside phosphonates with antiviral activity against retroviruses and DNA viruses.
– Phosphonate Functionalization: The diethyl ester enables conversion to prodrug forms improving oral bioavailability of derived APIs.
– Antiviral Research: Applied in developing novel nucleotide analogs for resistant viral strains and expanded antiviral applications.
Product Name: Diethylethoxy)methyl)phosphonate
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