(1R,2S)-2-fluorocyclopropan-1-amine;4-methylbenzenesulfonic acid
4-methylbenzenesulfonate salt of (1R,2S)-2-fluorocyclopropan-1-amine (CAS 143062-84-4), a single-enantiomer fluorinated cyclopropyl amine supplied as a white to off-white crystalline solid with a purity of 98 percent or higher and a reported boiling point near 418 degrees Celsius at 760 mmHg. The molecule pairs a small, strained cyclopropane ring bearing both a fluorine atom and a primary amino group with a tosylate counter-ion that improves crystallinity, thermal stability and ease of handling relative to the volatile free base. The fluorine substituent strongly influences basicity, lipophilicity and metabolic stability, while the rigid cyclopropane ring enforces a well-defined spatial orientation. It is an optically active pharmaceutical building block rather than an end product.
1. Chiral pharmaceutical intermediate: used to install the fluorocyclopropylamine motif into antibacterials, notably fluoroquinolone antibiotics such as sitafloxacin and related quinolone and naphthyridone derivatives, where the configuration markedly affects target binding and potency.
2. Medicinal chemistry building block: the fluorine atom modulates pKa, membrane permeability and oxidative metabolism, so this scaffold appears in kinase, central nervous system, antiviral and metabolic-disease discovery programmes and in structure-activity studies.
3. Salt-form advantage: the tosylate is a crystalline, non-hygroscopic salt that is easy to purify by recrystallisation and to weigh accurately on scale, and it releases the volatile free base cleanly on treatment with a base at the point of use.
4. Analytical and quality-control relevance: also used as a reference standard or chiral impurity marker in the analysis of fluoroquinolone drug substances. Store cool, dry and protected from light in a sealed container and avoid dust inhalation.
Product Name: (1R,2S)-2-fluorocyclopropan-1-amine;4-methylbenzenesulfonic acid
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