p-ethoxy)benzylamine
4-[2-(Dimethylamino)ethoxy]benzylamine (CAS 20059-73-8), also named p-(2-(dimethylamino)ethoxy)benzylamine or 2-(4-(aminomethyl)phenoxy)-N,N-dimethylethanamine, is a colourless to pale yellow oily liquid or low-melting solid containing two basic nitrogen atoms separated by an aromatic ether spacer. The molecule combines a primary benzylic amine with a tertiary dimethylamino group, giving it strong hydrogen-bonding and ionic character and excellent solubility in water and polar organic solvents. It is supplied as a research and pharmaceutical intermediate rather than a bulk commodity chemical, and it is normally stored sealed under inert gas at ambient temperature because the primary amine absorbs carbon dioxide and oxidises slowly during prolonged storage. Its practical value lies in the two chemically distinct amine handles it offers for selective derivatisation and in the basic ether chain it contributes to the final molecule.
1. Pharmaceutical intermediate: a building block for antihistamines, cardiovascular agents and central nervous system drugs containing the 2-dimethylaminoethoxy aryl motif, including diphenhydramine-type structures and calcium-channel or H1-receptor modulator analogues.
2. Heterocycle and ligand synthesis: the primary amine readily forms amides, imines, ureas, thioureas and cyclic products, while the tertiary amine provides a basic centre and can act as a metal ligand or phase-transfer catalyst in organic transformations.
3. Polymeric and material applications: used to prepare functional monomers, crosslinkers and surface modifiers bearing pendant tertiary amines or quaternary ammonium groups for coatings, membranes, ion-exchange resins and personal care polymers.
4. Handling and storage: corrosive and irritating to skin, eyes and respiratory tract; store sealed under inert gas, keep away from acids, alkylating agents and oxidising agents, and use appropriate protective equipment with local exhaust ventilation.
Product Name: p-ethoxy)benzylamine
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