4,5-Bis-2-nitrobenzonitrile
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile (CAS 236750-65-5) is a benzene ring carries two methoxyethoxy side chains, a nitro group and a nitrile group. It is recorded in the GSRS substance registry and is an established advanced intermediate and specified impurity of the anticancer drug erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor used in non-small-cell lung cancer and pancreatic cancer. The compound is soluble in polar organic solvents such as dimethyl sulfoxide and dimethylformamide, so stock solutions are easily prepared. It should be stored protected from light and heat and away from strong reducing agents, because the aromatic nitro group can undergo unwanted reduction to an amine under inappropriate storage conditions.
1. Erlotinib synthesis and impurity standard: a key intermediate and specified impurity in the manufacture of erlotinib and its salts, used for impurity identification, characterisation, origin assessment and control in the drug substance.
2. Pharmaceutical quality control: supports analytical method development, validation, relative response factor determination, batch release testing and stability studies for the erlotinib drug substance and its tablet formulations.
3. Medicinal chemistry value: illustrates how methoxyethoxy side chains tune aqueous solubility, metabolic clearance and pharmacokinetics of quinazoline-based kinase inhibitors, making the fragment a common design element in oncology programmes.
4. Handling and storage: keep sealed in a cool, dry, dark place away from strong oxidisers and reducing agents; avoid dust and vapour exposure, use protective equipment, and dispose of residues as regulated chemical waste.
Product Name: 4,5-Bis-2-nitrobenzonitrile
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