Vilanterol Intermediate A
CAS 503068-36-8, technically identified as an intermediate for the synthesis of Vilanterol, represents a sophisticated organic building block essential for modern pharmaceutical development. This compound typically features a benzodioxine scaffold functionalized with a pinacol boronate ester group, facilitating precise molecular construction through palladium-catalyzed cross-coupling methodologies. Its chemical profile makes it an indispensable component in the multi-step synthesis of long-acting beta-agonists utilized in respiratory medicine. In an industrial or research context, the material is recognized for its high degree of functionalization, allowing for the efficient assembly of complex pharmacophores. Proper handling involves maintaining the integrity of the boronic ester moiety, which is sensitive to protic environments and oxidative conditions. Consequently, it is typically managed within controlled laboratory or manufacturing environments to ensure high yields and purity in subsequent synthetic stages. As a high-value raw material, it serves as a critical bridge between basic chemical precursors and advanced therapeutic molecules, underscoring its importance in the global pharmaceutical supply chain.
• Primarily utilized as a key synthetic precursor in the production of Vilanterol, a potent long-acting beta2-adrenoceptor agonist. The compound provides the necessary structural framework for the benzodioxine moiety, which is integral to the pharmacological profile of the final active pharmaceutical ingredient (API).
• Serves as a versatile reagent in Suzuki-Miyaura cross-coupling reactions due to the presence of the tetramethyl-1,3,2-dioxaborolan-2-yl group. This functionality allows for the efficient formation of carbon-carbon bonds with various aryl or vinyl halides, enabling the construction of complex molecular architectures in medicinal chemistry research.
• Employed in the development of novel respiratory therapies and the optimization of synthetic routes for bronchodilators. Its role as a stable boronate ester makes it a preferred choice for researchers seeking to minimize side reactions during the assembly of sensitive heterocyclic systems.
• Utilized in large-scale pharmaceutical manufacturing processes where high-purity intermediates are required to meet stringent regulatory standards for API production. The compound’s specific substitution pattern ensures that the final therapeutic agent maintains the desired stereochemical and electronic properties for effective biological interaction.
Product Name: Vilanterol Intermediate A
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