N-Cbz-L-Aspartic acid (Z-L-Asp-OH)
N-Cbz-L-Aspartic acid, identified by CAS 1152-61-0 and often referred to as Z-L-Asp-OH, is a derivative of the proteinogenic amino acid L-aspartic acid. In this molecule, the amino group is protected by a benzyloxycarbonyl (Cbz or Z) group, which serves as a vital temporary masking agent during complex chemical transformations. It typically appears as a white to off-white crystalline powder and is valued for its high optical purity and stability under standard laboratory conditions.
This compound is a fundamental building block in the field of organic chemistry and peptide engineering. By shielding the N-terminus, it allows for the selective reaction of the carboxylic acid groups, facilitating the construction of specific peptide sequences without unwanted side reactions. Its handling requires standard laboratory precautions, typically involving storage in a cool, dry environment to maintain its chemical integrity for sensitive synthesis applications.
• In the field of peptide synthesis, N-Cbz-L-Aspartic acid is extensively utilized as a protected monomer for both solid-phase and solution-phase methodologies. The benzyloxycarbonyl group provides robust protection for the amine function, which can later be removed via hydrogenolysis or treatment with strong acids, allowing for the stepwise elongation of peptide chains with high regiospecificity.
• This derivative serves as a critical intermediate in the production of pharmaceutical precursors and bioactive molecules. It is frequently employed in the synthesis of aspartyl-containing peptides, which are components of various enzyme inhibitors and receptor ligands. Its use ensures that the acidic side chain of the aspartic acid residue can be manipulated or protected independently during the assembly of complex therapeutic candidates.
• Beyond peptide chemistry, CAS 1152-61-0 is used in the development of specialty chemicals and biochemical reagents. It acts as a chiral starting material for the synthesis of asymmetric compounds, including ligands for transition metal catalysis and chiral resolving agents. Researchers value its predictable reactivity and the ease with which the Cbz group can be managed throughout multi-step organic syntheses.
Product Name: N-Cbz-L-Aspartic acid (Z-L-Asp-OH)
For global customers, we provide complete technical documentation to support product evaluation, regulatory compliance and safe handling during transportation and application.