(E)-4-(Dimethylamino)but-2-enoic acid
(E)-4-(Dimethylamino)but-2-enoic acid, identified by CAS: 149586-32-3, is an organic compound characterized as a substituted crotonic acid. It features a dimethylamino group at the 4-position and exhibits a trans (E) configuration across the double bond. This structural motif makes it a valuable building block in specialized organic synthesis, particularly in the development of targeted therapeutic agents.
In industrial chemistry, this compound serves as a critical intermediate for the production of various active pharmaceutical ingredients. Its reactivity is derived from both the carboxylic acid functional group and the unsaturated chain, allowing for diverse chemical transformations. It is typically handled as a stable solid under standard storage conditions, requiring protection from moisture and light to maintain its chemical integrity during manufacturing processes.
• Used primarily as a key intermediate in the synthesis of Afatinib, a potent tyrosine kinase inhibitor employed in oncology for the treatment of non-small cell lung cancer.
• Serves as a versatile building block in medicinal chemistry for the introduction of the 4-(dimethylamino)-2-butenoyl moiety into various heterocyclic scaffolds.
• Utilized in research and development for the preparation of Michael acceptor derivatives, which are important in the design of irreversible enzyme inhibitors.
• Employed in fine chemical synthesis to produce specialized amino acid derivatives and unsaturated carboxylic acid analogues for biochemical studies.
Product Name: (E)-4-(Dimethylamino)but-2-enoic acid
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