4-Chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline
4-Chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline (CAS: 199327-59-8) is a specialized heterocyclic organic compound belonging to the quinazoline family. This substance serves as a critical building block in the synthesis of advanced pharmaceutical agents, particularly those targeting specific kinase pathways. Its molecular structure features a chloro-substituted quinazoline core with methoxy and morpholinopropoxy side chains, which are essential for the biological activity of the final molecules derived from this intermediate.
The compound is primarily utilized in research and development and large-scale pharmaceutical manufacturing. As a high-purity intermediate, it ensures the efficiency and quality of downstream chemical reactions. It is handled as a stable solid under recommended storage conditions, typically requiring protection from moisture and light to maintain its chemical integrity throughout the synthesis process. Its role is pivotal in the production of selective inhibitors used in targeted therapies.
• Serves as the primary intermediate in the synthesis of Gefitinib, a potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used in oncology.
• Utilized in medicinal chemistry research for the development of novel quinazoline-based derivatives aimed at treating various proliferative disorders and inflammatory conditions.
• Acts as a structural scaffold in organic synthesis, allowing for the introduction of diverse functional groups at the 4-position of the quinazoline ring through nucleophilic substitution.
• Employed in the optimization of chemical processes within the pharmaceutical industry to improve the yield and purity of active pharmaceutical ingredients (APIs).
Product Name: 4-Chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline
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