Pd(dppf)Cl2
Pd(dppf)Cl2 (CAS: 72287-26-4), the palladium(II) dichloride complex of 1,1′-bis(diphenylphosphino)ferrocene, is a robust, air-stable catalyst for cross-coupling reactions.
The wide bite angle of the dppf ligand gives strong activity and selectivity, particularly for Suzuki-Miyaura couplings of aryl halides and boronic acids and for borylation reactions.
It is widely used in pharmaceutical process chemistry and in the synthesis of OLED and other electronic intermediates.
The complex is air-stable as a solid and is simple to weigh and dose. Buyers typically check palladium content and iron content, appearance and residual solvents, which help ensure reproducible catalytic activity.
• Suzuki-Miyaura coupling: dependable catalyst for aryl-aryl bond formation, including with hindered or heteroaryl partners. It is often the first catalyst screened for challenging heteroaryl couplings.
• Miyaura borylation: converts aryl halides to boronic esters for further coupling steps. The reaction is a standard route to boronic acid pinacol esters used in later coupling steps.
• Pharmaceutical and electronic intermediates: supports scalable production of drug candidates and conjugated materials. Its reliability supports repeat orders for scale-up campaigns.
• Negishi, Kumada and Buchwald-type couplings: also applied in other cross-couplings and aminations that benefit from the large bite-angle ferrocenyl ligand.
Product Name: Pd(dppf)Cl2
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