1-Bromo-3,5-di-tert-butylbenzene
1-Bromo-3,5-di-tert-butylbenzene (CAS: 22385-77-9) is a sterically shielded aryl bromide supplied as a white to off-white crystalline solid. The bromide substituent makes it a versatile coupling partner for palladium-catalyzed cross-coupling reactions, while the two tert-butyl groups provide steric bulk that is useful in ligand, catalyst, and materials chemistry. It is used as a building block for specialty chemicals, polymer additives, and organic electronic materials where bulky aryl groups tune solubility and packing. The compound is a low-melting solid that is easy to handle, store, and dose in synthesis, and it dissolves in common organic solvents. Customers value its high purity, convenient solid form, and role as a reliable intermediate for constructing hindered aryl structures.
• Cross-coupling: an aryl bromide partner for Suzuki, Kumada, and Negishi couplings that build hindered biaryls for pharmaceutical and materials applications.
• Ligand synthesis: a precursor for sterically demanding phosphine and NHC ligand frameworks used in modern catalysis.
• Materials chemistry: building block for organic electronics, dendrimers, and functional aryl monomers where bulky substituents control packing and solubility.
• Specialty intermediates: applied where 3,5-di-tert-butylphenyl groups tune solubility, sterics, and thermal properties of finished products.
Product Name: 1-Bromo-3,5-di-tert-butylbenzene
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