4-(4-Aminophenyl)morpholin-3-one
4-(4-Aminophenyl)morpholin-3-one (CAS: 438056-69-0) is a white to off-white crystalline intermediate combining an aniline group with a morpholinone ring. It is a recognized building block in pharmaceutical synthesis, most notably as the key starting material for rivaroxaban, a widely prescribed oral anticoagulant. The free aniline function supports acylation, condensation, and coupling reactions, while the morpholinone scaffold contributes hydrogen-bonding capacity and binding performance in target molecules. The material is typically specified against tight impurity limits because downstream API quality depends on intermediate purity. Customers use it where a well-defined, high-purity heterocyclic amine intermediate is required for advanced API manufacture and process development.
• Anticoagulant APIs: a key intermediate in the synthesis of factor Xa inhibitors such as apixaban, supporting cardiovascular medicine production.
• Pharmaceutical building block: the aniline group supports acylation and condensation chemistry for complex molecule assembly.
• Heterocyclic chemistry: a morpholinone-containing amine for advanced intermediate design in discovery and process programs.
• Quality-critical supply: produced and traded against tight impurity specifications for downstream GMP API manufacturing.
Product Name: 4-(4-Aminophenyl)morpholin-3-one
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