4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one
4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one (CAS: 80841-78-7), commonly called DMDO-Cl, is a cyclic carbonate supplied as a colourless to light yellow clear liquid.
The two functional handles allow sequential substitution and esterification, and the dioxolone ring is designed to release the prodrug moiety after hydrolysis, which makes the compound a key intermediate for medoxomil-type pharmaceuticals.
Commercial assay is 98% with low moisture and free acid, and it is packed in drums as a moisture-sensitive chloromethyl reagent.
• Olmesartan medoxomil manufacture: supplies the medoxomil (dioxolone) prodrug moiety.
• Prodrug design: used to esterify acidic drugs and improve oral absorption.
• Pharmaceutical intermediates: a chloromethyl building block for substituted carbonates.
• Process chemistry: a convenient, bench-stable alternative to chloromethyl chloroformate routes.
Product Name: 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one
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