Alogliptin Intermediate (CAS: 865758-96-9) is a chlorinated pyrimidinedione bearing an ortho-cyanobenzyl group, supplied as a white to off-white crystalline powder.
The ortho-nitrile is ideally positioned to cyclise onto an amine of the aminopiperidine partner, closing the pyrimidinedione ring of alogliptin in the final steps of synthesis.
Commercial assay is 98% with controlled single chlorinated impurity, and it is packed in drums or bags under GMP-compatible conditions.
• Alogliptin manufacture: a late-stage intermediate in the synthesis of the DPP-4 inhibitor alogliptin benzoate.
• Antidiabetic process chemistry: a crystalline, well-defined intermediate with controlled chlorinated impurity.
• Heterocycle synthesis: a template for pyrimidinedione libraries.
• Analytical standards: a reference compound for genotoxic-impurity and related-substance testing.
Alogliptin Intermediate (CAS: 865758-96-9) is a chlorinated pyrimidinedione bearing an ortho-cyanobenzyl group, supplied as a white to off-white crystalline powder.
The ortho-nitrile is ideally positioned to cyclise onto an amine of the aminopiperidine partner, closing the pyrimidinedione ring of alogliptin in the final steps of synthesis.
Commercial assay is 98% with controlled single chlorinated impurity, and it is packed in drums or bags under GMP-compatible conditions.
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