This compound (CAS 853029-57-9) is a brominated purine-dione intermediate used in the synthesis of linagliptin, a DPP-4 inhibitor for type 2 diabetes. It is a white to off-white powder handled under pharmaceutical-grade conditions for process development and impurity profiling.
8-Bromo-7-but-2-ynyl-3-methyl-1-4-methylquinazolin-2-ylmethylpurine-26-dione
Category:Organic Intermediates
CAS No.:853029-57-9
Product Grade: Pharma grade
Purity / Assay: 98%
Molecular Formula:C₂₀H₁₇BrN₆O₂
Molecular Weight:453.29
EINECS No.:922-028-0
Synonym(s):8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione; Linagliptin intermediate
This compound (CAS 853029-57-9) is a brominated purine-dione intermediate used in the synthesis of linagliptin, a DPP-4 inhibitor for type 2 diabetes. It is a white to off-white powder handled under pharmaceutical-grade conditions for process development and impurity profiling.
1. Serves as a key brominated purine-dione intermediate for constructing the linagliptin xanthine core through selective N-alkylation and cyclization.
2. Functions as a reference impurity and process marker in DPP-4 inhibitor quality control and analytical method validation.
3. Supports route scouting, scale-up and registration batches for antidiabetic APIs.
4. Provides a versatile purine-dione building block for medicinal chemistry programs targeting xanthine-based enzyme inhibitors.
25kg/drum; 200kg/drum
CAS No.: 853029-57-9
Product Name: 8-Bromo-7-but-2-ynyl-3-methyl-1-4-methylquinazolin-2-ylmethylpurine-26-dione
Purity / Assay:98%
Molecular Formula:C₂₀H₁₇BrN₆O₂
Molecular Weight:453.29
EINECS No.:922-028-0
Synonym(s):8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione; Linagliptin intermediate
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