1-Chloro-2–4-iodobenzene
1-Chloro-2–4-iodobenzene (CAS: 1103738-29-9) is a dihalogenated aromatic compound featuring both chloro and iodo substituents with differentiated reactivity, enabling selective cross-coupling at the carbon-iodine bond while retaining the chlorine for subsequent transformations. The iodine participates readily in palladium-catalyzed Suzuki, Heck, Sonogashira, and Buchwald-Hartwig reactions under mild conditions, while the chloro group requires harsher conditions, providing orthogonal synthetic handles. This building block is employed in pharmaceutical synthesis for constructing complex biaryl systems, in agrochemical manufacturing for active ingredient elaboration, and in materials science for preparing conjugated polymers and liquid crystal compounds. The high purity and defined regiochemistry of this intermediate ensure predictable coupling selectivity. Proper storage protected from light maintains reactivity for demanding synthetic sequences requiring stepwise halogen functionalization.
– Selective Cross-Coupling: Used in Suzuki and Heck reactions at the C-I bond while preserving chlorine for subsequent transformation enabling sequential functionalization.
– Pharmaceutical Building Block: Serves as a scaffold for constructing diaryl and heteroaryl drug candidates through sequential coupling strategies.
– Materials Synthesis: Applied in preparing conjugated polymers, liquid crystals, and OLED materials requiring halogenated aromatic precursors.
– Agrochemical Intermediates: Employed in building crop protection molecules through stepwise palladium-catalyzed couplings.
Product Name: 1-Chloro-2–4-iodobenzene
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