2-Ethoxy-1-naphthoic acid
2-Ethoxy-1-naphthoic acid (CAS 2224-00-2) is a white to yellowish crystalline powder with a distinct odour that combines a naphthalene ring, an ethoxy substituent at the 2-position and a carboxylic acid at the 1-position. It is soluble in common organic solvents and only sparingly soluble in water, and its solubility behaviour in ethanol, methanol and other solvents has been measured and correlated in the crystallisation literature. Suppliers offer material of 99 percent purity or higher for synthetic use. The peri arrangement of the ethoxy and carboxylic acid groups creates steric congestion and a strong intramolecular interaction, which makes the molecule a useful intermediate for building substituted naphthalenes and naphthopyranone, naphthalide or naphtholactone ring systems employed in pharmaceuticals and specialty materials.
1. Pharmaceutical and fine chemical intermediate: used to prepare naphthalene-based drug candidates, including anti-inflammatory, antimicrobial and antiparasitic agents derived from substituted naphthoic acids and their heterocyclic derivatives.
2. Synthetic building block: the carboxyl group allows amide, ester, acid chloride, anhydride and reduction chemistry, while the ethoxy group can be cleaved to give a phenol for further elaboration, halogenation, alkylation and functionalisation.
3. Specialty materials: a precursor for naphthol-derived dyes, fluorescent probes, photochromic compounds, liquid crystal dopants and ligands for metal coordination and catalysis.
4. Handling and storage: irritant to skin, eyes and respiratory tract; store in a tightly closed container in a cool, dry, well-ventilated place away from strong oxidising agents, and avoid dust generation when weighing or charging the material.
Product Name: 2-Ethoxy-1-naphthoic acid
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