2,4-Imidazolidinedione, 5-ethoxy-1–
2,4-Imidazolidinedione, 5-ethoxy-1– (CAS: 65855-02-9), 1-benzyl-5-ethoxyimidazolidine-2,4-dione, is a substituted hydantoin featuring a benzyl group and an activated ethoxy substituent on the heterocyclic ring. The ethoxy group at the 5-position serves as a leaving group, enabling nucleophilic substitution with amines, alkoxides, and thiolates to introduce diverse functionality at this position. This reactivity makes the compound a versatile intermediate in pharmaceutical synthesis, particularly for constructing substituted hydantoins and related heterocyclic cores found in anticonvulsant and antiarrhythmic drug classes. The benzyl group provides a hydrophobic handle and can be removed by hydrogenolysis when required. Manufactured under controlled conditions to ensure high purity and defined stereochemistry at the 5-position, this intermediate supports efficient elaboration into complex therapeutic molecules through straightforward substitution chemistry.
– Hydantoin API Synthesis: Used as a key intermediate for introducing 5-amino or 5-thio functionality into hydantoin-based drug candidates.
– Nucleophilic Substitution: The activated ethoxy group enables clean displacement by amines and other nucleophiles under mild conditions.
– Anticonvulsant Intermediates: Serves in synthesizing phenytoin-class and novel antiepileptic compounds requiring substituted imidazolidinedione cores.
– Medicinal Chemistry: Applied in structure-activity studies of hydantoin derivatives for neurological and cardiovascular targets.
Product Name: 2,4-Imidazolidinedione, 5-ethoxy-1–
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