25-Hydroxyvitamin D3
25-Hydroxyvitamin D3, identified by CAS number 19356-17-3 and also known as calcifediol, is a critical metabolic intermediate in the vitamin D endocrine system. It is chemically characterized as a secosteroid produced in the liver through the hydroxylation of cholecalciferol. As the primary circulating form of vitamin D, this compound serves as the standard clinical indicator for assessing an individual’s vitamin D status. In its pure form, it typically appears as a white crystalline powder that is highly sensitive to light, air, and heat, requiring specialized handling and storage conditions to maintain its chemical integrity.
In research and industrial contexts, 25-Hydroxyvitamin D3 is valued for its role as a precursor to the biologically active form, calcitriol. It is widely utilized in the development of diagnostic assays and as a reference standard in analytical chemistry. Its solubility in organic solvents and specific spectroscopic properties make it a focal point for studies involving metabolic pathways, calcium homeostasis, and bone mineralization processes. The compound’s stability and purity are paramount for ensuring reproducible results in high-sensitivity laboratory applications.
• This compound serves as a fundamental reference material and analytical standard in the development and calibration of diagnostic kits, including liquid chromatography-mass spectrometry (LC-MS) and enzyme-linked immunosorbent assays (ELISA), which are designed to quantify vitamin D levels in biological fluids.
• In biochemical and physiological research, 25-Hydroxyvitamin D3 is employed to investigate the metabolic conversion processes within the liver and kidneys, helping scientists understand the regulation of calcium and phosphorus transport across cellular membranes and its subsequent impact on skeletal health.
• It is utilized in the formulation of specialized nutritional research diets and animal feed additives where a more direct metabolic precursor is required to bypass certain hepatic limitations, ensuring efficient systemic availability of the vitamin D metabolite for comparative studies.
• The material is frequently integrated into pharmaceutical research and development projects focused on endocrine disorders, where it acts as a substrate for enzymatic assays to evaluate the potency and efficacy of novel therapeutic agents targeting the vitamin D receptor or related metabolic enzymes.
Product Name: 25-Hydroxyvitamin D3
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