[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methanol
[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methanol (CAS: 278597-30-1) is a specialized organic intermediate primarily utilized in the synthesis of complex heterocyclic compounds. It features an isoxazole core substituted with a bulky 2,6-dichlorophenyl group and an isopropyl moiety, providing a specific spatial configuration essential for biological activity in medicinal chemistry. This compound serves as a critical building block for the development of various pharmaceutical agents, particularly those targeting nuclear receptors.
The molecule is valued for its high purity and stable crystalline form, making it suitable for large-scale chemical synthesis and laboratory research. Its unique structural features allow for further functionalization of the methanol group, enabling the creation of diverse derivatives. As a key intermediate, it plays a vital role in the pipeline of metabolic disease research and the production of therapeutic ligands.
• Used as a primary intermediate in the synthesis of Farnesoid X Receptor (FXR) agonists, which are investigated for the treatment of liver diseases such as primary biliary cholangitis and non-alcoholic steatohepatitis.
• Serves as a versatile building block in medicinal chemistry for the construction of isoxazole-based heterocyclic scaffolds, allowing for the introduction of specific pharmacophores through the modification of the hydroxymethyl group.
• Employed in the research and development of non-steroidal ligands for nuclear receptors, where the 2,6-dichlorophenyl substitution provides necessary steric hindrance and electronic properties for receptor binding.
• Utilized in organic synthesis laboratories for the preparation of complex organic molecules requiring a stable and functionalized isoxazole ring system.
Product Name: [3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methanol
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