3-Ethoxybenzaldehyde
3-Ethoxybenzaldehyde (CAS 22924-15-8), also called m-ethoxybenzaldehyde, is a colourless to brownish clear liquid with a strong aromatic aldehyde odour, a boiling point near 245 degrees Celsius and a melting point reported around 177 degrees Celsius. Suppliers list a purity of 97 to 98 percent for laboratory and industrial use, with good solubility in most common organic solvents and only slight solubility in water. The molecule contains an electron-rich ethoxy-substituted aromatic ring and a highly reactive aldehyde group, a combination that makes it a versatile electrophile. The ethoxy group can be selectively cleaved to give a phenol, while the aldehyde undergoes condensation, reduction, reductive amination, Grignard addition and Knoevenagel chemistry under mild conditions, giving chemists broad synthetic flexibility from a readily available feedstock.
1. Pharmaceutical and agrochemical intermediate: used to prepare substituted benzyl amines, benzyl alcohols, chalcones, hydrazones, oximes and Schiff bases for drug and crop-protection synthesis and for biological activity screening.
2. Flavour and fragrance chemistry: serves as a precursor for ethyl vanillin analogues, aromatic aldehydes, acetals and esters used in flavour, fragrance and aroma compositions for food and cosmetic applications.
3. Synthetic versatility: the aldehyde participates in aldol, Wittig, Henry, Cannizzaro, reductive amination and Grignard reactions, while dealkylation of the ethoxy group gives 3-hydroxybenzaldehyde for further derivatisation into dyes and antioxidants.
4. Handling and storage: a combustible liquid, irritating to skin and eyes and harmful if swallowed; keep in a tightly closed container away from oxidising agents and ignition sources, ground equipment during transfer, and avoid inhalation of the vapour.
Product Name: 3-Ethoxybenzaldehyde
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