4-amino-5-chloro-2-ethoxybenzoic acid
4-amino-5-chloro-2-ethoxybenzoic acid (CAS: 108282-38-8) is a trisubstituted benzoic acid featuring an amino group, chloro substituent, and ethoxy group in specific regiochemical arrangement. This substituted aniline derivative serves as a strategic intermediate in pharmaceutical synthesis, most notably for gastroprokinetic agents such as mosapride and related benzamide compounds. The free amino group enables diazotization, acylation, and reductive alkylation reactions, while the carboxylic acid provides a handle for amide bond formation to construct the benzamide pharmacophore. The chloro and ethoxy substituents modulate electronic properties and receptor binding characteristics of derived drugs. Manufactured under strict quality controls to ensure regiochemical purity and consistent assay, this intermediate supports efficient multi-step API synthesis. Proper storage away from oxidizing conditions preserves the sensitive amino functionality for downstream transformations.
– Gastroprokinetic Synthesis: Used as the key benzoic acid intermediate in manufacturing mosapride and related 5-HT4 receptor agonist drugs.
– Amide Formation: The carboxylic acid enables coupling with amines to construct substituted benzamide pharmaceutical cores.
– Aniline Chemistry: The free amino group supports diazotization and substitution reactions for further molecular elaboration.
– API Process Development: Serves in route optimization for substituted benzamide drug candidates and generic manufacturing.
Product Name: 4-amino-5-chloro-2-ethoxybenzoic acid
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