4-Pyrimidinol, 2,5,6-triamino-, hydrogen sulfate
4-Pyrimidinol, 2,5,6-triamino-, hydrogen sulfate (CAS: 1603-02-7), also named 2,4,5-triamino-6-hydroxypyrimidine sulfate, is a polyfunctional pyrimidine derivative closely related to guanine in structure. This white crystalline compound serves as a critical intermediate in the industrial synthesis of folic acid, where it provides the pyrimidine ring that is elaborated into the pterin portion of the vitamin molecule. Its multiple amino and hydroxyl functionalities permit selective cyclocondensation, diazotization, and coupling reactions under controlled conditions. The compound also finds application in the synthesis of dihydrofolate reductase inhibitors, xanthine derivatives, and other nitrogen-rich heterocycles of pharmaceutical interest. Produced under strict quality control to ensure high assay and minimal impurities, it supports reproducible multi-step syntheses. Proper storage away from moisture and heat maintains its reactivity for demanding downstream chemical transformations.
– Folic Acid Synthesis: Serves as the essential pyrimidine intermediate in commercial production of folic acid for food fortification and nutritional supplements.
– Antifolate Pharmaceuticals: Used in the manufacture of dihydrofolate reductase inhibitors and other pteridine-based therapeutic agents.
– Purine Analog Chemistry: Applied as a building block for xanthine, caffeine, and related heterocyclic compounds in pharmaceutical research.
– Specialty Dye Intermediates: Employed in the synthesis of heterocyclic dyes and optical brighteners requiring nitrogen-rich aromatic scaffolds.
Product Name: 4-Pyrimidinol, 2,5,6-triamino-, hydrogen sulfate
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