(4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester (CAS 154026-94-5) is a chiral acetonide-protected building block used in statin synthesis. It is a key intermediate for the HMG-CoA reductase inhibitor side chain, particularly in the preparation of rosuvastatin and related statins. The compound is handled as a colourless to light-yellow liquid under anhydrous conditions.
(4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester
Category:Organic Intermediates
CAS No.:154026-94-5
Product Grade: Industrial Grade
Purity / Assay: 97%
Molecular Formula:C₁₃H₂₃ClO₄
Molecular Weight:278.77
Synonym(s):tert-Butyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate; Rosuvastatin intermediate
(4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester (CAS 154026-94-5) is a chiral acetonide-protected building block used in statin synthesis. It is a key intermediate for the HMG-CoA reductase inhibitor side chain, particularly in the preparation of rosuvastatin and related statins. The compound is handled as a colourless to light-yellow liquid under anhydrous conditions.
1. Chiral intermediate for rosuvastatin and other HMG-CoA reductase inhibitors. 2. Building block for the heptenoic acid side chain of statin drugs. 3. Asymmetric synthesis of protected 1,3-diol intermediates. 4. Pharmaceutical process development for lipid-lowering agents.
25kg/drum; 200kg/drum
CAS No.: 154026-94-5
Product Name: (4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester
Purity / Assay:97%
Molecular Formula:C₁₃H₂₃ClO₄
Molecular Weight:278.77
Synonym(s):tert-Butyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate; Rosuvastatin intermediate
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