5-Chlorothiophene-2-carboxylic acid
5-Chlorothiophene-2-carboxylic acid (CAS: 24065-33-6) is a chlorinated thiophene building block supplied as a solid for organic synthesis. Its heteroaromatic ring and carboxylic acid group enable conversion to acyl derivatives and further functionalization, while the ring-bound chlorine provides an additional point of structural differentiation. Technical literature and published synthesis work document applications in rivaroxaban preparation and substituted thiophene intermediates. It is a chemical synthesis input, not an active pharmaceutical ingredient or finished medicine. Buyers should select specifications and handling controls appropriate to the intended process.
• Used as a starting acid in published rivaroxaban synthesis; a documented route converts it with thionyl chloride to the acid chloride, then couples it to an oxazolidinone-containing intermediate.
• Supplier information identifies it as a precursor to 5-chloro-4-nitrothiophene-2-carboxylic acid, a further building block for thieno[2,3-b][1,4]thiazepin-5-one derivatives.
• More generally, it is a heteroaromatic carboxylic-acid building block for synthesis research and process development involving substituted thiophene derivatives; downstream suitability depends on the specific route and required specification.
Product Name: 5-Chlorothiophene-2-carboxylic acid
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