Cefpirome sulfate
Cefpirome sulfate (CAS 98753-19-6) is a sophisticated fourth-generation cephalosporin derivative utilized primarily as a high-purity chemical intermediate and reference standard in pharmaceutical research. Chemically, it is characterized by its zwitterionic structure, featuring a quaternary ammonium group at the C-3 position of the cephem nucleus, which enhances its penetration through the outer membrane of Gram-negative organisms. As a sulfate salt, it typically appears as a white to pale yellow crystalline powder with high aqueous solubility. In laboratory and industrial settings, this compound is valued for its stability and predictable reactivity in synthetic pathways. Proper handling requires protection from light and moisture to maintain chemical integrity. Its role in the chemical industry centers on its use as a building block for advanced molecular synthesis and as a benchmark material for evaluating the efficacy of novel beta-lactamase inhibitors and other antimicrobial agents in developmental chemistry.
• Pharmaceutical Research and Development: Cefpirome sulfate serves as a critical reference material in the development of new cephalosporin-based compounds. Researchers utilize it to study the structure-activity relationships (SAR) of fourth-generation beta-lactams, particularly focusing on how specific side chains influence the bypass of porin channels and resistance to enzymatic degradation by beta-lactamases.
• Analytical Chemistry Standards: The compound is widely employed as an analytical standard for high-performance liquid chromatography (HPLC) and mass spectrometry (MS). It facilitates the calibration of equipment and the validation of testing methodologies for monitoring purity levels, degradation products, and residual concentrations in complex chemical matrices.
• Microbiological Studies: In vitro research applications involve using Cefpirome sulfate to investigate bacterial cell wall synthesis inhibition. It acts as a tool for understanding the binding affinity to penicillin-binding proteins (PBPs), providing data on the mechanisms of action for broad-spectrum cephalosporins against various microbial strains in a controlled laboratory environment.
• Chemical Synthesis: It functions as a precursor or intermediate in the synthesis of specialized chemical derivatives. Its unique structural features allow for further modification in the creation of complex heterocyclic molecules, making it a versatile component in the toolkit of medicinal and organic chemists.
Product Name: Cefpirome sulfate
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