Daptomycin

## Daptomycin (CAS 103060-53-3): Key Functions and Uses

1. **Cyclic Lipopeptide Antibiotic**
Daptomycin is a calcium-dependent cyclic lipopeptide antibiotic used against serious infections caused by susceptible **Gram-positive bacteria**. It is particularly important in hospital and infectious-disease settings where resistant bacterial pathogens may be involved.

2. **Treatment of Complicated Skin Infections**
Approved injectable formulations are used to treat complicated skin and skin-structure infections caused by susceptible organisms, including certain *Staphylococcus aureus*, *Streptococcus*, and *Enterococcus* species, according to local product labeling.

3. **Staphylococcus aureus Bloodstream Infections**
Daptomycin is used for selected *Staphylococcus aureus* bloodstream infections, including bacteremia. In approved indications, it may also be used for associated right-sided infective endocarditis under qualified medical supervision.

4. **Activity Against Resistant Gram-Positive Pathogens**
Daptomycin is valued in antimicrobial treatment strategies involving difficult-to-treat Gram-positive bacteria, including some methicillin-resistant *Staphylococcus aureus* (MRSA) and vancomycin-resistant *Enterococcus faecium* (VRE) infections. Susceptibility testing and infectious-disease expertise are essential.

5. **Calcium-Dependent Membrane Mechanism**
The drug binds to bacterial membranes in a calcium-dependent manner and disrupts membrane function, including membrane potential and ion balance. This rapid membrane-active mechanism ultimately inhibits essential bacterial processes and leads to cell death.

6. **Research and Antimicrobial Development**
CAS 103060-53-3 is used in microbiology, pharmaceutical research, antibacterial screening, pharmacology, resistance surveillance, susceptibility testing, and studies of bacterial membrane biology and antibiotic mechanisms.

7. **Quality and Procurement Considerations**
When sourcing Daptomycin, buyers should verify identity, purity, potency, sterility or non-sterile status, formulation, endotoxin specifications where relevant, certificate of analysis, storage conditions, and regulatory documentation. Useful SEO keywords include **Daptomycin, CAS 103060-53-3, cyclic lipopeptide antibiotic, Gram-positive antibacterial, MRSA research, bacteremia treatment, infective endocarditis, and antimicrobial research compound**.

8. **Important Medical and Safety Notice**
Daptomycin is a prescription antibacterial medicine and must be administered according to an authorized product label and professional medical guidance. Treatment may require monitoring for muscle-related toxicity, creatine phosphokinase changes, renal considerations, and drug interactions. Research-grade Daptomycin is for laboratory use only and is not intended for self-medication or unauthorized therapeutic application.