Ethane, 1-chloro-2-ethoxy-
Ethane, 1-chloro-2-ethoxy- (CAS: 628-34-2), commonly 2-chloroethyl ethyl ether, is a bifunctional ether featuring a reactive primary alkyl chloride alongside an ethoxy group. The chloromethyl terminus readily undergoes nucleophilic substitution with amines, alkoxides, thiolates, and carbanions, while the ether oxygen provides solubility and coordinative properties. This clear liquid serves as a versatile alkylating intermediate in pharmaceutical synthesis, crop protection chemistry, and specialty chemical manufacturing. It is employed to introduce 2-ethoxyethyl moieties into molecules, to construct morpholine and piperazine derivatives through double alkylation, and as a precursor for functional ethers and esters. The compound requires controlled handling due to its alkylating properties and lachrymatory character. With its straightforward reactivity and commercial availability, it remains a practical building block for constructing oxygen-containing carbon frameworks.
– Amine Alkylation: Used to prepare N-(2-ethoxyethyl) derivatives of amines, morpholines, and piperazines in pharmaceutical and agrochemical synthesis.
– Ether Synthesis: Serves as an alkylating agent for converting alcohols and phenols into 2-ethoxyethyl ethers with enhanced solubility properties.
– Pharmaceutical Intermediate: Applied in constructing side chains and linkers for drug candidates requiring flexible ether-containing spacers.
– Specialty Chemical Production: Employed as a building block for surfactants, solvent additives, and functionalized polymers.
Product Name: Ethane, 1-chloro-2-ethoxy-
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