Ethyl 3-Aminocrotonate
Ethyl 3-Aminocrotonate (CAS: 626-34-6) is an enamine ester supplied as a pale yellow clear liquid that may solidify at low temperature.
The molecule combines a nucleophilic amino group with an electrophilic ester on an activated double bond, so it undergoes condensation with carbonyls, amidines and hydrazines to close five- and six-membered nitrogen heterocycles in a single step.
Typical commercial assay is 98% with low water content, and the product is stored cool under inert gas to limit hydrolysis.
• Pyrimidine and pyridine synthesis: condenses with amidines and hydrazines to close heterocyclic rings in one step.
• Calcium channel blockers: a building block for 1,4-dihydropyridine type actives.
• Veterinary and pharmaceutical intermediates: used to assemble substituted aminopyrimidines.
• Agrochemicals: a component for preparing herbicidal and fungicidal heterocycles.
Product Name: Ethyl 3-Aminocrotonate
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