Glycine Benzyl Ester p-Toluenesulfonate
Glycine Benzyl Ester p-Toluenesulfonate (CAS: 114342-15-3) is a protected amino acid derivative featuring glycine’s benzyl ester paired with p-toluenesulfonic acid. The benzyl group protects the carboxylic acid during peptide synthesis and can be removed by hydrogenolysis under mild conditions, while the tosylate salt provides a crystalline, stable form facilitating handling and storage. This compound serves as a fundamental building block in peptide synthesis, enabling stepwise chain elongation with minimal racemization. It also functions as a starting material for N-substituted glycine derivatives, heterocyclic compounds, and pharmaceutical intermediates where glycine’s simple structure provides a flexible scaffold. The salt form’s excellent solubility in polar organic solvents supports efficient coupling reactions. With its proven utility in amino acid chemistry and reliable deprotection profile, this derivative is a staple reagent for pharmaceutical research and peptide manufacturing.
– Peptide Synthesis: Used as a carboxyl-protected glycine building block in solid-phase and solution-phase peptide assembly for pharmaceutical development.
– Hydrogenolysis Deprotection: The benzyl ester is cleanly removed by catalytic hydrogenation enabling mild, selective deprotection in multi-step routes.
– N-Substituted Glycine Synthesis: Serves as a precursor for sarcosine derivatives and peptoid building blocks in medicinal chemistry.
– Heterocycle Construction: Applied in synthesizing diketopiperazines, morpholinones, and other glycine-derived heterocycles.
Product Name: Glycine Benzyl Ester p-Toluenesulfonate
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