N-(4-Trifluoromethylphenyl)thiourea
N-(4-Trifluoromethylphenyl)thiourea is a thiourea bearing a trifluoromethyl group on the aromatic ring, supplied as a white crystalline powder at 98% purity.
The trifluoromethyl group is strongly electron-withdrawing and highly lipophilic, which raises the acidity of the thiourea protons, strengthens hydrogen bonding and improves membrane permeability; the sulfur atom remains an effective metal-binding site. These properties make the compound a popular scaffold in medicinal chemistry and a useful ligand in coordination studies.
The powder should be stored in a dry, closed container away from strong oxidising agents, and dust should be controlled during weighing and transfer.
• Pharmaceutical building block: a common intermediate for aminothiazoles, thiazolidinones and other heterocycles in drug discovery.
• Agrochemical intermediates: used to prepare herbicidal and fungicidal thiourea derivatives bearing a CF3 group.
• Ligand and catalyst studies: coordinates transition metals for catalytic and analytical applications.
• Biochemical research: applied as an inhibitor scaffold in enzyme-activity and antiproliferative studies.
Product Name: N-(4-Trifluoromethylphenyl)thiourea
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