Netilmicin sulfate
Netilmicin sulfate (CAS 56391-57-2) is a semi-synthetic aminoglycoside derived from sisomicin, characterized by its robust stability against various aminoglycoside-modifying enzymes. As a sulfate salt, it typically appears as a white to off-white, hygroscopic powder with high solubility in aqueous media. Its chemical structure features a complex aminocyclitol ring system, which is essential for its biological activity. This material is primarily utilized as a high-purity raw material in laboratory settings and pharmaceutical development, where its specific chemical profile is leveraged for specialized research applications.
In the context of chemical handling, Netilmicin sulfate requires controlled storage conditions, typically involving protection from light and moisture to maintain its structural integrity and potency. It is recognized for its relative resistance to common bacterial resistance mechanisms that affect other aminoglycosides, such as gentamicin or tobramycin. This makes it a valuable tool for researchers investigating antimicrobial resistance patterns or developing new formulations. Its role as a chemical intermediate or analytical standard is critical in ensuring the precision of microbiological assays and chemical characterization studies.
• In microbiological research and diagnostic development, Netilmicin sulfate serves as a potent selective agent in culture media. It is utilized to study the susceptibility of various gram-negative and gram-positive organisms, providing a benchmark for evaluating the efficacy of novel antimicrobial compounds. Its ability to withstand enzymatic degradation by certain bacterial strains makes it a critical component in assays designed to differentiate between specific resistance phenotypes.
• Within the pharmaceutical manufacturing sector, this compound acts as a primary active pharmaceutical ingredient for the formulation of sterile injectable solutions and ophthalmic preparations. Its high water solubility and stability in solution facilitate the creation of concentrated liquid dosages. Manufacturers rely on this raw material to produce therapeutic agents aimed at addressing severe infections, ensuring that the final products meet rigorous purity and potency standards required for industrial output.
• Netilmicin sulfate is extensively employed as an analytical reference standard in quality control laboratories. It is used to calibrate high-performance liquid chromatography and other spectroscopic instruments to ensure the accurate quantification of aminoglycosides in complex matrices. This application is vital for monitoring production consistency, verifying the concentration of active ingredients, and conducting stability testing over the shelf life of finished chemical products.
Product Name: Netilmicin sulfate
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