Phenyllithium
Phenyllithium (CAS:591-51-5) is the parent aromatic organolithium reagent, supplied as a solution in dibutyl ether. It is used for arylation, metal-halogen exchange and deprotonation in pharmaceutical and materials synthesis, combining strong nucleophilicity with predictable selectivity and convenient handling in standardized solution form. With its Industrial Grade designation, every lot carries a complete certificate of analysis including assay, purity and physical data, giving QC teams everything needed for release testing. The product is backed by flexible 25kg/drum, 200kg/drum packaging, steady stock availability and export documentation, so customers can plan procurement with confidence and keep production running without interruption.
KieRay Chem is recognized as a reliable partner for Phenyllithium (CAS:591-51-5), with dedicated production capacity, strict process control and a proven global track record. Batch-to-batch reproducibility is guaranteed by standardized production and full QC release, with COA, technical datasheets and safety files delivered with every order. Customized grades, pack sizes and dependable delivery schedules help customers maintain uninterrupted production and end-product quality worldwide. With a strong export record and customer-first service, KieRay Chem ensures every tonne of product meets the highest standards of purity and safety.
## Phenyllithium (CAS 591-51-5): Key Functions and Uses
1. **Powerful Organolithium Reagent**
Phenyllithium, also known as **PhLi**, is a highly reactive organolithium compound used in advanced organic and organometallic synthesis. Its strong basicity and nucleophilicity make it valuable for generating reactive intermediates and promoting difficult chemical transformations.
2. **Phenyl Group Transfer Reagent**
One of the main functions of Phenyllithium is the transfer of a phenyl group to suitable electrophiles. It is commonly used to introduce phenyl structures into organic molecules, supporting the synthesis of aromatic alcohols, ketones, hydrocarbons, and other functionalized compounds.
3. **Carbonyl Addition Reactions**
Phenyllithium can react with aldehydes, ketones, esters, and related carbonyl compounds to form new carbon–carbon bonds. This application is important for constructing complex molecular frameworks in **organic synthesis, medicinal chemistry, and pharmaceutical intermediate development**.
4. **Strong Base for Deprotonation and Metalation**
As a strong Brønsted base, Phenyllithium is used to remove acidic hydrogen atoms and generate lithio intermediates. These intermediates can undergo further reactions, enabling controlled functionalization and the preparation of valuable organometallic compounds.
5. **Applications in Pharmaceutical and Specialty Chemical Research**
Phenyllithium is useful in the preparation of research compounds, pharmaceutical building blocks, agrochemical intermediates, and specialty chemicals. Its ability to form carbon–carbon bonds makes it valuable for route development, reaction mechanism studies, and laboratory-scale process optimization.
6. **Value for Materials and Organometallic Chemistry**
Researchers may use Phenyllithium in studies involving organometallic mechanisms, aromatic compounds, functional materials, and polymer-related chemistry. It can help explore new reaction pathways and support the development of tailored molecular structures.
7. **Quality and Procurement Considerations**
When purchasing **Phenyllithium 591-51-5**, buyers should verify concentration, solvent, purity, packaging, batch consistency, certificate of analysis, storage conditions, and technical support. Useful search terms include **Phenyllithium, PhLi, CAS 591-51-5, organolithium reagent, phenylating reagent, strong base, and synthetic chemistry reagent**.
8. **Professional Safety Requirement**
Phenyllithium is highly reactive and may ignite in air or react violently with water and incompatible substances. It should be handled only by trained professionals in properly equipped facilities, in accordance with the supplier’s Safety Data Sheet and applicable regulations. It is intended for professional research and industrial use only.
Product Name: Phenyllithium
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