Pivaloyl Chloride
Pivaloyl Chloride (CAS: 3282-30-2) is a colorless, moisture-sensitive acyl chloride liquid used to introduce the sterically bulky pivaloyl group into alcohols, phenols, and amines. It is a versatile acylation reagent for pharmaceutical and agrochemical synthesis, including pivaloyloxymethyl prodrug intermediates for antibiotics, and serves as a protecting-group reagent in complex molecule assembly. The trimethylacetyl group blocks unwanted reactions while being removable under controlled conditions. The compound is moisture- and heat-sensitive, so material is stored under inert gas and packed in sealed drums. Customers select it where a bulky C5 acylating agent is required.
• Acylation reagent: introduces the bulky pivaloyl group into alcohols, phenols, and amines.
• Prodrug chemistry: a source of pivaloyloxymethyl (POM) prodrug intermediates for certain antibiotics.
• Protecting group: the trimethylacetyl group shields reactive sites during complex molecule synthesis.
• Handling: moisture- and heat-sensitive liquid stored under inert gas in sealed drums.
Product Name: Pivaloyl Chloride
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