Sodium Picosulfate
Sodium Picosulfate (CAS: 10040-45-6) is a stimulant laxative used in human medicine and bowel preparation products. Chemically the disodium salt of 4,4′-(pyridin-2-ylmethylene)bisphenol bis(hydrogen sulfate), it acts as a locally effective prodrug that is hydrolyzed by colonic bacteria to release the active diphenolic metabolite, which directly stimulates colonic motility and promotes bowel evacuation. Because of its targeted activation in the large intestine, it produces predictable laxative effects with minimal systemic absorption, making it valuable for the relief of constipation and for bowel cleansing prior to surgical or diagnostic procedures such as colonoscopy. Supplied as a high-purity pharmaceutical-grade white powder, it is formulated into oral liquids, sachets, and combination products with osmotic agents. Its well-characterized pharmacology and favorable safety profile support its widespread use in gastroenterology and hospital practice.
– Constipation Relief: Formulated as an oral stimulant laxative for the short-term treatment of occasional constipation with predictable overnight action.
– Bowel Preparation: Used alone or in combination with osmotic laxatives for complete bowel cleansing before colonoscopy, surgery, and radiological examination.
– Hospital and Clinical Use: Employed in perioperative protocols and diagnostic preparation kits to ensure effective, well-tolerated intestinal evacuation.
Product Name: Sodium Picosulfate
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