tert-Butyl Bromoacetate
tert-Butyl Bromoacetate (CAS: 5292-43-3) is a colorless to pale yellow liquid alkylating agent that combines an activated bromomethylene group with an acid-labile tert-butyl ester. It is widely used to introduce the bromoacetate unit into amines, alcohols, and other nucleophiles, serving as a precursor for pharmaceuticals, agrochemicals, and specialty chemicals including glycine derivatives, ether acids, and quaternary ammonium compounds. The tert-butyl ester is easily removed under mild acidic conditions, giving convenient access to carboxylic acids after alkylation. The liquid is moisture-tolerant and dispenses easily at room temperature. Buyers value its high reactivity, clean conversion, and flexible deprotection in multi-step synthesis.
• Alkylation chemistry: introduces bromoacetate groups onto amines, phenols, and thiols for further elaboration.
• Pharmaceutical intermediates: used to build glycine, ether-acid, and quaternary ammonium motifs in drug synthesis.
• Agrochemicals: a precursor for herbicide and pesticide intermediates based on aryloxyacetate structures.
• Deprotective flexibility: the tert-butyl ester is cleaved under mild acid to reveal the free carboxylic acid.
Product Name: tert-Butyl Bromoacetate
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