Vilanterol Intermediate B
CAS 503068-37-9, commonly recognized as Vilanterol Intermediate B, is a sophisticated organic building block essential for the synthesis of advanced pharmaceutical compounds. Chemically identified as 2,2-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-1,3-benzodioxine, this compound serves as a critical structural component in the production of long-acting beta2-adrenoceptor agonists. Its molecular architecture, featuring a protected benzodioxine core and a boronate ester moiety, makes it highly reactive in cross-coupling reactions, particularly the Suzuki-Miyaura coupling. As a high-purity intermediate, it facilitates the precise assembly of complex molecular frameworks required for respiratory therapeutic agents. In industrial and research settings, the material is handled as a fine chemical, requiring adherence to standard laboratory safety protocols and controlled storage conditions to maintain its chemical integrity. Its availability is vital for pharmaceutical manufacturers focusing on high-efficiency synthetic routes, ensuring consistent quality and yield during the multi-step synthesis of active pharmaceutical ingredients. This intermediate represents a key link in the chemical supply chain for modern medicinal chemistry.
• The primary application of CAS 503068-37-9 is as a key synthetic intermediate in the production of Vilanterol, a potent long-acting beta2-adrenoceptor agonist used in the treatment of chronic obstructive pulmonary disease and asthma. The compound provides the essential benzodioxine moiety that characterizes the molecular structure of the active pharmaceutical ingredient, allowing for the precise construction of the pharmacophore necessary for biological activity.
• This material serves as a crucial reagent in Suzuki-Miyaura cross-coupling reactions due to its pinacol boronate ester functional group. This functionality enables the efficient formation of carbon-carbon bonds with various aryl or vinyl halides under mild catalytic conditions. Its high reactivity and selectivity make it a preferred choice for chemists looking to streamline complex synthetic pathways while maintaining high yields and minimizing the formation of unwanted by-products in multi-step organic synthesis.
• Beyond its specific role in Vilanterol production, the compound is utilized in medicinal chemistry research for the development of novel structural analogs and related heterocyclic derivatives. Its unique protected diol structure allows for further chemical modifications, providing a versatile platform for exploring structure-activity relationships in the design of new therapeutic agents. It is also employed in process chemistry to optimize manufacturing scales, ensuring the scalability and reproducibility of pharmaceutical chemical processes.
Product Name: Vilanterol Intermediate B
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