Diethyl [methyl]phosphonate
Diethyl [methyl]phosphonate (CAS: 116384-56-6) is a functionalized phosphonate intermediate featuring a diethyl phosphonate group and a chloromethyl substituent for nucleophilic elaboration. This compound serves as a versatile building block in the synthesis of antiviral nucleotide phosphonates, most notably intermediates toward tenofovir and related acyclic nucleoside analogs. The chloromethyl group undergoes substitution with nucleobases and other
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